ATC provides services to aircraft in flight between airports as well. Pilots fly under one of two sets of rules for separation: Visual Flight Rules (VFR) or Instrument Flight Rules (IFR). Air traffic controllers have different responsibilities to aircraft operating under the different sets of rules. While IFR flights are under positive control, in the US VFR pilots can request flight following, which provides traffic advisory services on a time permitting basis and may also provide assistance in avoiding areas of weather and flight restrictions. In the UK, a pilot can request for "Deconfliction Service", which is similar to flight following.
En-route air traffic controllers issue clearances and instructions for airborne aircraft, and pilots are required to comply with these instructions. En-route controllers also provide air traffic control services to many smaller airports around the country, including clearance off of the ground and clearance for approach to an airport. Controllers adhere to a set of separation standards that define the minimum distance allowed between aircraft. These distances vary depending on the equipment and procedures used in providing ATC services.

General characteristics

En-route air traffic controllers work in facilities called Area Control Centers, each of which is commonly referred to as a "Center". The United States uses the equivalent term Air Route Traffic Control Center (ARTCC). Each center is responsible for many thousands of square miles of airspace (known as a Flight Information Region) and for the airports within that airspace. Centers control IFR aircraft from the time they depart from an airport or terminal area's airspace to the time they arrive at another airport or terminal area's airspace. Centers may also "pick up" VFR aircraft that are already airborne and integrate them into the IFR system. These aircraft must, however, remain VFR until the Center provides a clearance.
Center controllers are responsible for climbing the aircraft to their requested altitude while, at the same time, ensuring that the aircraft is properly separated from all other aircraft in the immediate area. Additionally, the aircraft must be placed in a flow consistent with the aircraft's route of flight. This effort is complicated by crossing traffic, severe weather, special missions that require large airspace allocations, and traffic density. When the aircraft approaches its destination, the center is responsible for meeting altitude restrictions by specific points, as well as providing many destination airports with a traffic flow, which prohibits all of the arrivals being "bunched together". These "flow restrictions" often begin in the middle of the route, as controllers will position aircraft landing in the same destination so that when the aircraft are close to their destination they are sequenced.
As an aircraft reaches the boundary of a Center's control area it is "handed off" or "handed over" to the next Area Control Center. In some cases this "hand-off" process involves a transfer of identification and details between controllers so that air traffic control services can be provided in a seamless manner; in other cases local agreements may allow "silent handovers" such that the receiving center does not require any co-ordination if traffic is presented in an agreed manner. After the hand-off, the aircraft is given a frequency change and begins talking to the next controller. This process continues until the aircraft is handed off to a terminal controller ("approach").

Radar coverage

Since centers control a large airspace area, they will typically use long range radar that has the capability, at higher altitudes, to see aircraft within 200 nautical miles (370 km) of the radar antenna. They may also use TRACON radar data to control when it provides a better "picture" of the traffic or when it can fill in a portion of the area not covered by the long range radar.
In the U.S. system, at higher altitudes, over 90% of the U.S. airspace is covered by radar and often by multiple radar systems; however, coverage may be inconsistent at lower altitudes used by unpressurized aircraft due to high terrain or distance from radar facilities. A center may require numerous radar systems to cover the airspace assigned to them, and may also rely on pilot position reports from aircraft flying below the floor of radar coverage. This results in a large amount of data being available to the controller. To address this, automation systems have been designed that consolidate the radar data for the controller. This consolidation includes eliminating duplicate radar returns, ensuring the best radar for each geographical area is providing the data, and displaying the data in an effective format.
Centers also exercise control over traffic travelling over the world's ocean areas. These areas are also FIRs. Because there are no radar systems available for oceanic control, oceanic controllers provide ATC services using procedural control. These procedures use aircraft position reports, time, altitude, distance, and speed to ensure separation. Controllers record information on flight progress strips and in specially developed oceanic computer systems as aircraft report positions. This process requires that aircraft be separated by greater distances, which reduces the overall capacity for any given route. See for example the North Atlantic Track system.
Some Air Navigation Service Providers (e.g. Airservices Australia, The Federal Aviation Administration, NAV CANADA, etc.) have implemented Automatic Dependent Surveillance - Broadcast (ADS-B) as part of their surveillance capability. This new technology reverses the radar concept. Instead of radar "finding" a target by interrogating the transponder, the ADS-equipped aircraft sends a position report as determined by the navigation equipment on board the aircraft. Normally, ADS operates in the "contract" mode where the aircraft reports a position, automatically or initiated by the pilot, based on a predetermined time interval. It is also possible for controllers to request more frequent reports to more quickly establish aircraft position for specific reasons. However, since the cost for each report is charged by the ADS service providers to the company operating the aircraft, more frequent reports are not commonly requested except in emergency situations. ADS is significant because it can be used where it is not possible to locate the infrastructure for a radar system (e.g. over water). Computerized radar displays are now being designed to accept ADS inputs as part of the display. This technology is currently used in portions of the North Atlantic and the Pacific by a variety of states who share responsibility for the control of this airspace.
Precision approach radars are commonly used by military controllers of airforces of several countries, to assist the Pilot in final phases of landing in places where Instrument Landing System and other sophisticated air borne equipements are unavailable to assist the pilots in marginal or near zero visibility conditions. This procedure is also called Talkdowns.
A Radar Archive System (RAS) keeps an electronic record of all radar information, preserving it for a few weeks. This information can be useful for search and rescue. When an aircraft has 'disappeared' from radar screens, a controller can review the last radar returns from the aircraft to determine its likely position. For example, see this crash report. RAS is also useful to technicians who are maintaining radar systems.

Flight traffic mapping

The mapping of flights in real-time is based on the air traffic control system. In 1991, data on the location of aircraft was made available by the Federal Aviation Administration to the airline industry. The National Business Aviation Association (NBAA), the General Aviation Manufacturers Association, the Aircraft Owners & Pilots Association, the Helicopter Association International, and the National Air Transportation Association petitioned the FAA to make ASDI information available on a "need-to-know" basis. Subsequently, NBAA advocated the broad-scale dissemination of air traffic data. The Aircraft Situational Display to Industry (ASDI) system now conveys up-to-date flight information to the airline industry and the public. Some companies that distribute ASDI information are FlightExplorer, FlightView, and FlyteComm. Each company maintains a website that provides free updated information to the public on flight status. Stand-alone programs are also available for displaying the geographic location of airborne IFR (Instrument Flight Rules) air traffic anywhere in the FAA air traffic system. Positions are reported for both commercial and general aviation traffic. The programs can overlay air traffic with a wide selection of maps such as, geo-political boundaries, air traffic control center boundaries, high altitude jet routes, satellite cloud and radar imagery.